Beneath conditions of very low CB1R density, THC antagonises endogenous agonists possessing greater receptor efficacy than THC19. THC also allosterically modulates opioid receptors20, which can supply extra indirect routes for altering dopamine transmission21. Also, THC has psychoactive metabolites with CB1R affinity, even more complicating the analyses of receptor binding studies22. https://car-crash-compensation54949.blog2freedom.com/33058656/rumored-buzz-on-cannabis-strains